Sirpa CLIA Kit for Rat(Rattus norvegicus) | EIAab.comSirpa CLIA Kit for Rat(Rattus norvegicus)

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Sirpa (Gene name),

Tyrosine-protein phosphatase non-receptor type substrate 1 (Protein name ), SHPS1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Sirpa(Bit;Mfr;Ptpns1;Shps1;Sirp);

Protein name:

Tyrosine-protein phosphatase non-receptor type substrate 1(SHP substrate 1;SHPS-1);

Alternative:

CD172 antigen-like family member A;Brain Ig-like molecule with tyrosine-based activation motifs(Bit);Macrophage fusion receptor;Inhibitory receptor SHPS-1;Signal-regulatory protein alpha-1(Sirp-alpha-1);Macrophage membrane protein MFP150;

CD:

CD172a;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.

Function:

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. May play a role in the release of nitric oxide by macrophages.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

509

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

509:

YASVQVQRK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:25528

Pfam:

PF07654

SMR:

P97710

String:

P97710

UniGene:

Rn.53971

STRING:

10116.ENSRNOP00000006408

Uniprot:

P97710

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ELISA Kit for Rat SHP substrate 1

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E9001m

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96T

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ELISA Kit for Rat SHP substrate 1

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E9001b

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ELISA Kit for Rat SHP substrate 1

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E9001h

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96T

ELISA Kit for Rat SHP substrate 1

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E9001r

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96T

CLIA Kit for Rat SHP substrate 1

Cat.:

U9001r

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96T

CLIA Kit for Rat SHP substrate 1

Cat.:

U9001m

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MSDS:

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Packing:

96T

CLIA Kit for Rat SHP substrate 1

Cat.:

U9001b

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MSDS:

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Packing:

96T

CLIA Kit for Rat SHP substrate 1

Cat.:

U9001h

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96T

Polyclonal Antibody for Rat SHP substrate 1

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P9001Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat SHP substrate 1

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P9001Rb-h

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Polyclonal Antibody for Rat SHP substrate 1

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P9001Rb-r

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Monoclonal Antibody for Rat SHP substrate 1

Protein for Rat SHP substrate 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion."
Fujioka Y. , Matozaki T. , Noguchi T. , Iwamatsu A. , Yamao T. , Takahashi N. , Tsuda M. , Takada T. , Kasuga M.
Mol. Cell. Biol.16:6887-6899(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 42-60; 68-91; 128-137; 150-158; 174-189; 192-202; 204-212; 218-237; 259-270; 279-282; 405-415 AND 446-453;GLYCOSYLATION;PHOSPHORYLATION AT TYROSINE RESIDUES;INTERACTION WITH PTPN6 AND PTPN11
tissue: Fetal fibroblast.
2.

"BIT, an immune antigen receptor-like molecule in the brain."
Sano S. , Ohnishi H. , Omori A. , Hasegawa J. , Kubota M.
FEBS Lett.411:327-334(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 32-48 AND 446-453;FUNCTION;PHOSPHORYLATION AT TYROSINE RESIDUES
strain: Sprague-Dawley.
tissue: Brain.
3.

"MFR, a putative receptor mediating the fusion of macrophages."
Saginario C. , Sterling H. , Beckers C. , Kobayashi R. , Solimena M. , Ullu E. , Vignery A.
Mol. Cell. Biol.18:6213-6223(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 99-107; 128-149; 192-217; 405-417; 419-429; 446-467 AND 496-506;GLYCOSYLATION;TISSUE SPECIFICITY
strain: Fischer 344.
tissue: Macrophage.
4.

"Signal-regulatory protein is selectively expressed by myeloid and neuronal cells."
Adams S. , van der Laan L.J.W. , Vernon-Wilson E. , Renardel de Lavalette C. , Doepp E.A. , Dijkstra C.D. , Simmons D.L. , van den Berg T.K.
J. Immunol.161:1853-1859(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-419;TISSUE SPECIFICITY
strain: WAG/Rij.
tissue: Alveolar macrophage.
5.

Lubec G. , Kang S.U. , Lubec S.
Submitted (2007-09) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 192-203; 218-226 AND 297-307;IDENTIFICATION BY MASS SPECTROMETRY
strain: Sprague-Dawley.
tissue: Brain.
6.

"Epidermal growth factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2, a SH2 domain-containing protein tyrosine phosphatase."
Ochi F. , Matozaki T. , Noguchi T. , Fujioka Y. , Yamao T. , Takada T. , Tsuda M. , Takeda H. , Fukunaga K. , Okabayashi Y. , Kasuga M.
Biochem. Biophys. Res. Commun.239:483-487(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION IN RESPONSE TO EGF;INTERACTION WITH PTPN11
7.

"Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation."
Takada T. , Matozaki T. , Takeda H. , Fukunaga K. , Noguchi T. , Fujioka Y. , Okazaki I. , Tsuda M. , Yamao T. , Ochi F. , Kasuga M.
J. Biol. Chem.273:9234-9242(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-477 AND TYR-501;MUTAGENESIS OF TYR-436; TYR-460; TYR-477 AND TYR-501

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